Lymphocyte Rich Classical Hodgkin’s Lymphoma (LRCHL) is a type of Hodgkin’s disease that is a cancer of lymph cells. It is one of the rarer types of Hodgkin’s disease comprising about 5 to 6% of all cases of this type of cancer. Though it has its own distinctive features, it is often mistaken for Nodular Lymphocyte Predominant Hodgkin's Lymphoma (NLPHL), another type of Hodgkin's lymphoma.
LRCHL can occur at any age, though most patients are usually in their 40s and 50s, and is more common in males than in females.
The predominant warning sign of this disease is an enlargement of lymph nodes in the neck, chest or armpits. Involvement of other lymph nodes or other organs is quite uncommon. Other symptoms of lymphoma include fever, weight loss and sweating at night. The diagnosis of lymphoma is made with a lymph node biopsy. The exact type of lymphoma is determined by molecular tests on biopsy tissue that can tell between this form of lymphoma and others.
The majority of patients with LRCHL are diagnosed with early stage lymphoma, involving lymph nodes only in one or two regions. Treatment of LRCHL includes chemotherapy and often radiation therapy as well. Most patients respond well to treatment and many are cured.
Cancer: Principles and Practice of Oncology 7th Edition. Editors: VT DeVita, S Hellman and SA Rosenberg. Published by Lippincott Williams and Wilkins, 2005.