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Types of Hodgkin Lymphoma

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Updated January 06, 2007

The report of the biopsy may indicate the type of Hodgkin Lymphoma that has occurred. There are five main types of Hodgkin Lymphoma. They differ in whom it affects, the parts of the body more likely to be affected, and in what stage it is usually diagnosed.

Nodular Sclerosing Hodgkin Lymphoma (NSHL):

This is the most common type of Hodgkin Lymphoma. In the developed countries 60-80% of the people affected by Hodgkin disease have the Nodular Sclerosing subtype. It is commoner in females and mostly affects younger people – adolescents and young adults. The disease mainly affects nodes in the neck or armpits, or within the chest.

Mixed Cellularity Hodgkin Lymphoma (MCHL):

This is another common type of Hodgkin Lymphoma. 15-30% of those affected have mixed cellularity disease. This type is more common in developing countries. People of any age may be affected. Males and females are equally affected. This type of disease is more likely to involve the abdomen than the more common nodular sclerosing variety, and less likely to involve nodes within the chest.

Lymphocyte Depleted Hodgkin Lymphoma (LDHL):

The Lymphocyte depletion subtype is a very rare form of Hodgkin Lymphoma that makes up only about 1% of those affected by the disease. It affects older people and is often diagnosed in an advanced stage when the lymphoma has affected different organs of the body. It is also more common in those who are HIV affected.

Lymphocyte-rich Classic Hodgkin Lymphoma (LRCHL):

This is another uncommon subtype that makes up about 5-6% of Hodgkin patients. It is more common in males and affects people most commonly in their thirties or forties. Most individuals are diagnosed in early stages and response to treatment is excellent.

Nodular Lymphocyte Predominant Hodgkin Lymphoma (NLPHL):

Now considered to be a special type of Hodgkin disease that is different from the other types mentioned above, this variant accounts for 4-5% of all cases of Hodgkin disease. According to pathologists this type has many similarities with Non-Hodgkin Lymphoma (NHL). In all clinical aspects, however, the features are similar to the lymphocyte-rich type of Hodgkin lymphoma. Most individuals are diagnosed early and do very well after treatment.

Does the treatment depend on the type of disease?:

Usually not. The treatment of Hodgkin disease depends mainly on the extent of involvement (the stage) and not on the type of disease. In certain circumstances however, the type of disease may predict the chances of certain areas of the body being affected, and may influence the doctors’ choice of treatment modality.

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