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What is Nodular Sclerosing Hodgkin’s Lymphoma?


Updated May 22, 2014

Nodular sclerosing Hodgkin’s lymphoma, a cancer of lymph cells, is a type of Hodgkin’s disease. It is the most common type of Hodgkin’s lymphoma in the developed countries, accounting for 60 to 80% of all individuals affected by this disease. Nodular sclerosing Hodgkin’s lymphoma affects mostly adolescents and young adults. It is also slightly more common in girls than boys. The name ‘nodular sclerosing’ is derived from the appearance of lymph node tissue under the microscope in this type of Hodgkin’s lymphoma.

The main symptoms of nodular sclerosing Hodgkin’s lymphoma are enlarged lymph nodes in the neck, armpits or within the chest. The diagnosis of lymphoma is made with a lymph node biopsy.

Most individuals are diagnosed in early stages and can be cured with treatment that includes chemotherapy and radiation therapy.


Cancer: Principles and Practice of Oncology 7th Edition. Editors: VT DeVita, S Hellman and SA Rosenberg. Published by Lippincott Williams and Wilkins, 2005.

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